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Inventi Impact: Molecular Pharmacology

Articles

  • Inventi:pmp/29344/19
    In Vitro Toxicity Study of a Porous Iron(III) Metal-Organic Framework
    Research 2019 : July - September
    Gongsen Chen, Xin Leng, Juyuan Luo, Longtai You, Changhai Qu, Xiaoxv Dong, Hongliang Huang, Xingbin Yin, Jian Ni

    A MIL series metal-organic framework (MOF), MIL-100(Fe), was successfully synthesized\nat the nanoscale and fully characterized by TEM, TGA, XRD, FTIR, DLS, and BET. A toxicological\nassessment was performed using two different cell lines: human normal liver cells (HL-7702) and\nhepatocellular carcinoma (HepG2). In vitro cytotoxicity of MIL-100(Fe) was evaluated by the MTT\nassay, LDH releasing rate assay, DAPI staining, and annexin V/PI double staining assay. The safe\ndose of MIL-100(Fe) was 80micro g/mL. It exhibited good biocompatibility, low cytotoxicity, and high\ncell survival rate (HL-7702 cellsâ?? viability >85.97%, HepG2 cellsâ?? viability >91.20%). Therefore,\nMIL-100(Fe) has a potential application as a drug carrier.

    How to Cite this Article
    Attribution/ CC Compliant Citation: Chen, Gongsen, et al. \"In Vitro Toxicity Study of a Porous Iron (III) Metalâ??Organic Framework.\"\nMolecules 24.7 (2019): 1211.\nhttps://doi:10.3390/molecules24071211\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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